About > The "Genetic code: Mechanisms, Evolution and Engineering" meeting

Meeting on

Genetic code: Mechanisms, Evolution and Engineering

Co-organized in Strasbourg March 26-28, 2020

by the

Société Française de Biochimie et de Biologie Moléculaire

and the

Société Française de Génétique


The genetic code was unraveled some 55 years ago, in a short period of time, but through arduous and insightful chemical and biochemical experimental designs. Formally, the genetic code is a cypher, a frozen table of correlations between two sets of letters with few variations. Viewed at the molecular level, however, the code as we now know it appeared in stages as a result of the complex molecular recognition and selection processes full of contingencies at the core of the transition from chemistry to biology in biological evolution. In the last twenty years a wealth of structures of active ribosomes and components of the translation apparatus has appeared. We now have a rich diversity of structures at sufficient resolution to integrate biochemical and biological observations in congruence with molecular data.

In this meeting, co-organized by the Société Française de Biochimie et de Biologie Moléculaire (SFBBM) and the Société Française de Génétique (SFG), the structural constraints operational during ribosomal translation will be described with their functional and organizational impacts on the cellular integration and homeostasis analyzed from various angles. Fifteen internationally known speakers from four different European countries have already accepted to present their last results. They will speak on four broad themes: ribosome structures and decoding, translational variations and miscoding, evolution and code optimization, ribosome engineering and code expansion. Topics will cover structures and kinetics of translation, neuronal translation, the interplay between translation and metabolism, the origins of the code and metabolism, and engineering of the code.

Most importantly, a number of slots are kept for talks chosen from the received abstracts. This process will give the opportunity to speak to young scientists and allow for unexpected or recent new results to be presented and discussed. Two poster sessions are also planned to encourage exchange and discussions.

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